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( Tnf, Il6, Il1b ) and downregulates pro-fibrotic genes ( Acta2, Col1a2, Tgfb1, Pdgfrb, Pdgf-b, Pdgf-c ), reducing -smooth muscle actin (-SMA) and platelet-derived growth factor receptor beta (PDGFR) protein levels (73)

doi:10.3978/j.issn.1000-9604.2013.09.03

Patients were seen to reduce their weight, and soon the medication was extended to patients desiring weight loss