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The number of pens needed monthly depends on the prescribed dose: Red Label Pen (0.25mg/0.5mg): Contains 6 doses total Provides 4 doses of 0.25mg and 2 doses of 0.5mg Blue Label Pen (1mg) and Yellow Label Pen (2mg): Each contains 4 doses One pen typically lasts 4 weeks Healthcare providers will prescribe the appropriate pen type based on the patient's maintenance dose

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However, the further clinical development of pramlintide/metreleptin combination therapy has been discontinued by the manufacturing companies because of safety concerns [249](Table 3 )