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In line with this evidence, the current study demonstrated a discontinuation rate below 2%, which was lower compared to that reported for PDE5i, and drop-out was unrelated to l-ARG safety profile, being merely determined by patient personal poor confidence concerning the potential benefits of supplementation

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Edick et al., 2020)

Effect of melatonin supplementation on sleep quality: a systematic review and meta-analysis of randomized controlled trials