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Thus, two HAMD subdomain scores were calculated: (a) depressive HAMD symptoms as the sum of sad mood + feelings of guilt + suicidal thoughts + loss of interest

Experimental studies have led to the identification of various cancer cell-intrinsic resistance mechanisms, e.g., activation and/or overexpression of drug transporter proteins (e.g., P-glycoprotein), altered expression of detoxifying enzymes (e.g., glutathione S-transferase) or resistance to apoptosis/senescence pathways [239-242]

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