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It is currently indicated for use in adults with obesity (with a BMI of 30 kg/m2 or greater) or overweight adults (with a BMI of 27 kg/m2 or greater) who also have weight-related medical problems such as type 2 diabetes, high blood pressure, obstructive sleep apnea, or cardiovascular disease

While this research explores pathways for infrastructure transformation, particularly in housing, transport, and networked services (Savini & Bossuyt, 2022

164 Protein intake in adults should not fall below 0.4-0.5 g/kg/d, as this can lead to muscle atrophy and functional impairments, whereas prolonged intake at or above 2 g/kg/d should be avoided due to potential adverse health effects

Collectively, current evidence supports a model [Figure 1B] in which: (1) a large fraction of early MASH resolution in ESSENCE is likely explained by significant weight loss and associated metabolic reprogramming