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10.1038/nm.4222 63 EstakiM.PitherJ.BaumeisterP.LittleJ

A RCT verified that patients treated with NAC had higher GSH levels in PBMCs, along with upregulated Foxp3 expression and suppressed mTOR activity (lower expression of phosphorylated S6 protein), which ultimately resulted in lower anti-dsDNA antibody titers and SLEDAI scores (Clinicaltrials.gov: NCT00775476) (255)