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Similarly, in Kctd13 (a gene within 16p11.2 CNV) haploinsufficient and knockout mice, there was an increase in RhoA expression coupled with deficiencies in synaptic signalingan effect that was ameliorated with Rhosin treatment [137]

Although some animals are very sensitive to biotin deficiency during pregnancy, a link between biotin deficiency and adverse effects in the mother and the developing fetus has not been observed in humans

Barrera JG, Sandoval DA, D'Alessio DA, Seeley RJ