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Trials with liraglutide 1.8 mg have shown weight loss up to 3.6% (3.3 kg) at 26 weeks and 4.7% (5.0 kg) at 56 weeks in subjects with T2D (171173), while trials with liraglutide 3.0 mg have shown weight loss of between 7.9% (8.9 kg) and 8.2% (7.3 kg) at 56 weeks in subjects with obesity (173175)

The combined signaling creates thermogenic effects that neither GLP-1 nor GIP activation produces on its own

So GLP-1 agonists mimic the naturally occurring GLP-1 hormone

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