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As a matter of fact, MTHFR C677T polymorphism has been shown to increase risk of PD in Europeans (92, 93), and Asians (93) with conflicting data (92), and has been shown to significantly increase risk of Migraine in Asians (94)

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Targeted improvement of mitophagy abnormality may become a novel strategy to prevent and treat metabolic diseases in the future

In the oxidant recovery assay both mitochondrial sensors behaved like the cytosolic sensorfollowing diamide washout they recovered rapidly to the respective steady states with similar kinetics (Figure 2B)