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Pharmaceutical-grade semaglutide (Ozempic, Wegovy, Rybelsus, and Health Canada-authorized generic versions) is manufactured to meet the formulation, sterility, packaging, and labelling requirements for human use under prescription, and is treated by Health Canada as a biologic product

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Its discovery traces back over 150 years to research on glucosuria ( By blocking sodium-glucose cotransporter 2 in the S1 and S2 segments of the proximal tubule, SGLT2i significantly reduce glucose reabsorption, promoting urinary glucose excretion

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