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What is the safety of long-term usage

doi: 10.2147/vhrm.s4039

These genetic factors do not determine medication response alone, but they can provide context for understanding individual variability in efficacy and side-effect patterns

Adverse ocular events included 47 cases of blurred vision (33.6%), 23 cases of diabetic retinopathy (16.4%), and 4 (2.9%) cases of macular complications