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Unfortunately, various defects, such as oxidative stress and mitochondrial dysfunction, could hinder oocyte maturation ( In addition, research has found that high levels of CoQ10 in the follicular fluid were associated with improved embryo morphokinetic parameters and higher pregnancy rates ( in vitro maturation rate of immature oocytes in patients with endometriosis compared to those who do not receive the supplement ( in vitro maturation has been found to increase oocyte maturation rates and decrease postmeiotic aneuploidies in women aged 38-46 ( In vitro studies have shown that a concentration of 50 M CoQ10 in culture media elevates the expression of Sirt1, a key regulator of mitochondrial function, in cumulus cells

10.1006/nbdi.2002.0563 150 ShafieeA.Teymouri AtharM

Prep Biochem Biotechnol

B., Weimer, P., & Rossi, R