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reported that GLP-1RAs can promote the overactivation of GLP-1R in pancreatic cells, which not only increases susceptibility to pancreatic inflammation but also increases the risk of pancreatic cancer

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for some [dulaglutide (Gerstein et al., 2019), liraglutide (Marso et al., 2016) and semaglutide (Marso et al., 2017)], the CVOTs also confirmed a cardiovascular benefit and eventually led to the approved use of these GLP-1 RAs to reduce cardiovascular risk in people with type 2 diabetes and established CVD or at high cardiovascular risk (Honigberg et al., 2020)