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These models permit the testing not only of thyroid hormone replacement but also act as a vehicle to test putative interventions for developmental deficits due to thyroid hormone insufficiency (Kim et al

Mitochondrial ferritin (FtMt), a mitochondria-localized iron storage protein with iron-binding affinity comparable to cytosolic ferritin [80], contributes to the maintenance of mitochondrial iron homeostasis [81]

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