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doi: 10.31491/apt.2020.03.014

The molecule is 4.3 amino acids smaller than EGF but still 68 percent over the passive transepidermal absorption ceiling

Notably, EV-associated DAMPs have been found in stored red blood concentrates [238], suggesting that eryptosis-mediated generation of EVs might exert immunomodulatory DAMP-triggered effects

Figure 3 below summarizes these processes, highlighting the interplay between bacterial infection, immune mediators (e.g., TNF-, IL-6, transforming growth factor-beta [TGF-], IL-10), and cellular actors (e.g., neutrophils, M1/M2 macrophages, fibroblasts, keratinocytes, endothelial cells) during wound healing [43, 48]