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d,1-alpha-Tocopheryl acetate (vitamin E): a long term toxicity and carcinogenicity study in rats

Under physiological conditions, ROS are generated in the heart mainly from the mitochondrial electron transport chain, nitric oxide synthases (NOS), NADPH oxidases (NOX), and xanthine oxidase (XO) in small quantities [7, 8]

Here's the breakdown: Alcohol (ethanol) gets converted by your liver into acetaldehyde, a compound that's significantly more toxic than alcohol itself

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