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[DOI] [PubMed] [Google Scholar] 12.Glucagon-like peptide-1 (GLP-1) receptor agonists and their cardiovascular benefits-the role of the GLP-1 receptor

FDA 2013)

In mammalian cells, Bcl-2 associated X protein (BAX) is recruited when various endogenous and exogenous stimuli induce apoptosis and form pores in the mitochondrial membrane [41], facilitating the release of Cyto-C (as a well conserved electron-transport protein and a part of the respiratory chain localized in mitochondrial intermembrane space.) into the cytoplasm

It plays a crucial role in glucose homeostasis by: Enhancing insulin secretion from pancreatic beta cells in a glucose-dependent manner [8] [9] Suppressing glucagon release , thereby reducing hepatic glucose production Slowing gastric emptying , which moderates postprandial glucose excursions Promoting satiety through actions on appetite centres in the brain GLP-1 receptor agonists mimic these physiological effects but with extended half-lives, allowing for once-weekly or once-daily administration