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M.Jr (1998)

Teduglutide for the treatment of adults with intestinal failure associated with short bowel syndrome: pooled safety data from four clinical trials

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Supporting this concept, a recent preclinical study demonstrated that chronic exposure to the absorption enhancer SNAC significantly altered gut microbial community structure, reduced the abundance of saccharolytic bacteria and fecal butyrate levels, and was associated with changes in inflammatory markers, suggesting that components of the oral formulation itself may influence hostmicrobiome interactions independently of systemic GLP-1 receptor activation (53)