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Studies have confirmed that IGFs play important roles in drug resistance in tumors, including the IGF-1/IGF-2/IGF-1R signaling axis and the IGFBP family members that reduce the susceptibility of cancers such as lung and breast cancers to chemotherapy resistance (130,131)

Venous blood samples were obtained just before dosing and 20, 40 min, 1, 1.5, 2, 3, 4, 6, 8, 10 and 12 h after the administration of NAC 600 mg

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Peptides were desalted using ZipTip -C18 Pipette Tips (Thermo Scientific) and were analyzed by an Orbitrap Fusion Tribrid coupled to a Nano-LC Proxeon 1000 equipped with an easy spray ion source (all from Thermo Scientific)