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This Comment highlights emerging evidence and advocates for clinical strategies that prioritize muscle preservation to ensure the long-term success and safety of pharmacological weight management

Semaglutide, the active compound in Ozempic, has transformed weight management for millions, yet specific medical conditions and histories make it unsuitable for certain individuals

Sample size was determined based on practical considerations, prior experience with similar phase 1 study designs, and the objective of obtaining sufficient safety and pharmacokinetic data to support dose escalation decisions

Because Lilly (until recently) couldnt get its supply chain together, I experienced frequent treatment interruptions