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But mechanism alone does not prove a clinical outcome

TNF inhibitor adalimumab reduces TNF-activated phosphorylation of serine 536 residues in NF-B p65, with degradation of inhibitor of B (IB, and the levels of TNF and interleukin-6 (IL6) expression in A1-40 induced AD mice [167]

Other inhibitors Paricalcitol restores GPX4 expression by activating VDR, improves renal function, reduces mitochondrial damage, and alleviates cisplatin-induced AKI [163, 171, 179]

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