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We identified highly deregulated pathways in iSPN + mut, with changes already apparent at 3 months

This process was not induced by other monoamine receptors and seems to be mediated by dopamine receptor activation via a noncanonical signaling pathway in which dopamine receptors trigger PKC activation and calcium release by activating D1-like receptors (Nickoloff-Bybel et al., 2019)

The role of dopamine in the progression of PD is quite complex and not fully understood