Key Points Long-acting modified IGF-1 analog Studied for extended IGF-1 receptor signaling IGF-1 mediates downstream growth-hormone effects Researched in growth and repair models Research Context IGF-1 LR3 is studied as a long-acting research analog in growth-signaling and cell-research contexts
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eLife 12 , RP88742 (2024)
Given the observed increased risk of colorectal cancer among patients receiving GLP-1 receptor agonists, clinicians should approach long-term prescribing of these agents with careful consideration, particularly in individuals with additional risk factors for colorectal cancer, such as a family history, obesity, inflammatory bowel disease, or long-standing type 2 diabetes
