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In this study, we observed a positive correlation between changes in serum GSSG levels and reductions in both the total PANSS scores and positive symptom scores among ECT responders, suggesting that the redox state changes correspondingly with the improvement to clinical symptoms

Restoration experiments then introduce exogenous glutathione or precursors and measure recovery of redox markers, enzyme activity, and viability parameters, establishing causal relationships between GSH levels and cellular outcomes