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[112] showed that the use of IN NPs delivery system enables the administration of a selective opioid receptor (DOR) agonist, leucine-kephalin hydrochloride (LENK), to the brain

10.1172/JCI138697 J Clin Invest

Over time, there are also potential concerns to consider: Skin thinning (atrophy) with prolonged use Worsening of symptoms after stopping treatment In some cases, a condition called topical steroid withdrawal , which may involve burning, stinging, or rebound flares after discontinuation Not everyone experiences these issues

International Journal of Molecular Sciences 22(18):9656