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Moreover, a caspase B (CTSB)-responsive programmed targeted delivery system D&R-HM-MCA can achieve TAM-targeted delivery, and the outer angiopep-2 modification can be cleaved off by CTSB-responsive peptides when it reached the tumor site, exposing the para-aminophenyl--d-mannopyranoside (MAN) modification which can further recognize glucose transporter-1 (GLUT1) on tumor cells and macrophage mannose receptors (MMR) on TAMs, inducing TAMs polarization from the anti-inflammatory M2 phenotype to the pro-inflammatory M1 phenotype thereby improving antitumor immune responses (59)
Stress response pathways in early embryos reflect their ability to cope with suboptimal culture conditions and environmental stresses that are inherent in assisted reproductive technology procedures [401]
Supplementation may be most relevant for individuals with documented oxidative stress, certain genetic polymorphisms affecting glutathione metabolism, or conditions like autoimmune disease or chronic fatigue where antioxidant support is clinically considered
