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There is a great risk to consumers if poor compounding practices are used, the settlement document states
GH replacement using physiologic doses of 0.21.0 mg/day (estimated range for an 80 kg person based on various units used to report dosing regimens among studies) in this setting is associated with improvements in body composition (increases in lean mass and decreases in fat mass) in some studies (Bengtsson, Eden, Lonn et al., 1993, Salomon, Cuneo, Hesp et al., 1989, Snel, Brummer, Doerga et al., 1995, Lonn, Johansson, Sjostrom et al., 1996, Jorgensen, Thuesen, Muller et al., 1994, Woodhouse, Asa, Thomas et al., 1999, Blackman, Sorkin, Munzer et al., 2002), although other reports looking directly at muscle cross sectional area showed no changes over a 6-month period (Cuneo, Salomon, Mcgauley et al., 1992)