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As a major presynaptic autoreceptor, it inhibits cyclic adenosine monophosphate (cAMP) levels by activating Gi/o proteins, thereby reducing NPY/AGRP release and suppressing feeding behavior

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Biological characteristics of GLP-1RAs Molecular structure and pharmacological properties Due to the suboptimal in vivo stability of the native GLP-1 peptide, GLP-1RAs were engineered with structural modifications that mimic endogenous GLP-1 while achieving a prolonged duration of action [15]

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