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After starting medication, regular blood tests are important to make sure the dose is working well
It must be remembered that estradiol exerts some of its direct effects on satiety through these same neuronal populations
However, the potential of this drug class was turbocharged by the FDAs December 2017 approval of Novo Nordisks weekly injectable Ozempic (semaglutide) and May 2018 approval of Eli Lillys dual agonist Mounjaro (tirzepatide), both for type 2 diabetes
Recently, a real-world study showing association between incretin-based therapy and changes in taste perception with GLP-1 or dual GLP-1/GIP-RAs usage for around 40 weeks reported that independently to weight loss, there was an increase in sweet perception intensity up to 4.7 times and salt perception up to 3.2 times in around 20% of the participants, resulting as well in earlier satiety, and reduction of hunger and craving due to a major sensibilization to both flavors with any of these medication, although they did not mention further impact in weight loss or BMI change (170)
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