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There are no generic versions of Zepbound or Mounjaro available in the U.S., says Shapiro

Gastrointestinal side effects are well-documented with GLP-1 therapy and may indirectly affect fluid balance

In conclusion, GLP-1RAs promoted macrophage polarization towards the M2 type, improving the inflammatory microenvironment of the synovium, maintaining synovial homeostasis, and inhibiting the progression of RA