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Effects on bone may be indirect, mediated through weight loss, changes in calcitonin, or other pathways rather than direct receptor activation in bone tissue

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The classical somatomedin hypothesis (Salmon and Daughaday, 1957, foundational sulfation factor research) assumed all peripheral IGF-1 came from this hepatic source

FDA approved Wegovy (semaglutide 2.4 mg) for chronic weight management in adults with obesity or overweight and at least one weight-related condition