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A vial that was sterile when compounded may harbor bacteria, fungi, or other microorganisms weeks or months after the BUD, especially if it has been punctured multiple times

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And thats why it comes down to, I think, the simple rule for people if theyre going to do some sort of metabolic switch, some sort of intermittent fast, it would be like, okay, lets try to at least stop eating 3 hours before bed because then youre at least going to be extending that fast somewhat by 3 hours, right