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Two new actions of topiramate: Inhibition of depolarizing GABAA-mediated responses and activation of a potassium conductance

Moreover, it was reported that supplementing the diet with the antioxidants N -acetylcysteine and vitamin E markedly increases tumor progression and reduces survival in mouse models of B-RAF- and K-RAS-induced lung cancer, by reduction of ROS, DNA damage, and p53 expression (Sayin et al., 2014)

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In: Beck DE, Roberts P, Saclarides TK, Senagore AJ, Stamos MJ, Wexner SD, editors