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5.5 Synergy with other bioactives in reducing OS burden Melatonins pleiotropy, direct radical scavenging, mitochondrial protection, and transcriptional control of antioxidant defenses make it a natural hub for combination strategies targeting the redox-endocrine axis in female reproduction (201)

Expression of TNF-, a target for NF-B and a cytokine strongly implicated in estrogen-deficiency bone loss, was suppressed in osteoclasts by 17- estradiol and NAC

In a 6-month trial of rhGH in GH-deficient adults, liver fat fraction fell from a mean of 12.4% to 7.8% (P 30, type 2 diabetes, or alcohol use disorder, add a FibroScan or hepatic ultrasound to establish a steatosis baseline before initiating therapy

[6, 12] Tocilizumab, a humanized monoclonal antibody against the IL-1 and IL-6 receptors, was also used as these patients often had high levels of these cytokines