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The FDAs vote follows a 2023 reclassification that pulled BPC-157 out of the reach of licensed compounding pharmacies

To evaluate their genuine leukemogenic potential, researchers engineered a lentiviral CRISPR-Cas9 system that can induce the t(11;19)/MLL-ENL translocation in human CD 34+ HSPCs

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The genetic causes of SCD include homozygosity for the rs334 mutation (HbSS, commonly referred as SCA) and compound heterozygosity between rs334 and mutations that lead to either other structural variants of -globin (such as HbC, causing HbSC) or reduced levels of -globin production as in -thalassemia (causing HbS/-thalassemia)