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Studies demonstrate that LPS activates adipose tissue macrophages via TLR4 receptors, promoting the release of proinflammatory cytokines such as TNF-, which in turn induces excessive lipolysis in adipocytes, generating large quantities of free fatty acids (FFAs) ( 3.5 Hypothalamic-pituitary-ovarian axis disruption Disruption of gut microbiota leading to systemic LPS translocation not only impairs peripheral organ function but also exacerbates PCOS pathology by interfering with the neuroendocrine regulation of the HPO axis (56)
Anticancer effects of methotrexate in combination with -tocopherol and -tocopherol succinate on triple-negative breast cancer
Amino acid abnormalities in infants with extrahepatic biliary atresia and cirrhosis
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