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Most of these oxygen metabolites are free radicals (H 2 O 2 is a non-radical ROS, but can easily be converted to free radicals), which have one or more unpaired electrons making them highly reactive (Reference Halliwell and Gutteridge44)

demonstrated that the glucagon-like peptide-1 receptor (GLP-1R) agonist exendin-4 (EX-4) inhibits ROS production and MMP-9 activation by activating the Wnt/-catenin signaling pathway in a rat model of temporary middle cerebral artery occlusion

H.GwakN.-G.ImY.-S.LeeK.-Y.SohnY.et al (2012)

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