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In contrast, apitegromab and trevogrumab target pro-MSTN and the latent complex, which helps minimize such side effects.[75,76] An additional noteworthy finding from studies on these two antibodies is that they not only increased muscle mass but also reduced fat mass.[75,76] This supports the notion that comprehensive MSTN inhibition, from its inactive forms to the mature form, represents a promising strategy for treating muscle loss in conjunction with metabolic disorders (Fig