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J Clin Endocrinol Metab 63: 492-498, 1986

Tozer, R.G., et al., Cysteine-rich protein reverses weight loss in lung cancer patients receiving chemotherapy or radiotherapy

In the context of lipotoxicity, small extracellular vesicles (sEVs) secreted by -cells exhibit altered protein and lipid compositions, contributing to -cell dysfunction and apoptosis (181)

Their multifactorial benefits extend beyond glucose regulation and may influence clinical outcomes through systemic vascular and neuroprotective mechanisms