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While the authors do acknowledge that "concerns had previously been raised about possible detrimental effects of the administration pimobendan to dogs with preclinical MMVD", they provide nothing to explain what role pimobendan played in those sudden and unexpected cardiac-related deaths

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Considering that many chronic age-related diseases appear to have some degree of mitochondrial dysfunction as part of their etiology, it is notable that alterations in mGSH homeostasis may be a central factor in this dysfunction