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"We are pleased to make this crucial medication available to patients who need it

BvPLA2 causes microglial inactivation and decreases CD4+ T cell recruitment (Figure 3) (Jafarzadeh et al., 2023)

Finally, we only used immunohistochemical staining to demonstrate the expression of GLP-1R in thyroid tissue

These results place orforglipron firmly in the range of effective GLP-1 therapies, though the trials used different patient populations and durations than the landmark semaglutide and tirzepatide studies