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10.1073/pnas.2002200117 Proc

* Correspondence: Na Wu, [email protected] These authors have contributed equally to this work and share first authorship Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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Only methylcobalamin and adenosylcobalamin can have an immediate health-promoting effect - all other forms of vitamin B12 must first be converted by the body into methylcobalamin or adenosylcobalamin in order to be active as coenzymes in the organism