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The most commonly reported adverse effects in Phase 2 trials were gastrointestinal in nature, including: Nausea (the most frequently reported) Vomiting Diarrhoea Constipation Decreased appetite These effects were generally dose-dependent and most pronounced during dose escalation, typically improving over time

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Lee H, Zandkarimi F, Zhang Y, Meena JK, Kim J, Zhuang L, Tyagi S, Ma L, Westbrook TF, Steinberg GR, et al

Weight loss was truly slow, most likely due to persistent insulin resistance. A six-month course of Ozempic helped the woman lose 46 pounds (21 kg), from 235 pounds (107 kg) to 189 pounds (86 kg) [26]