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Hsu et al used the TriNetX platform to study the association between semaglutide use and the incidence of NAION and found that it was associated with an increased risk in patients with diabetes at the 2-, 3-, and 4-year timepoints but not within 1 year of GLP-1 RA initiation

They target the exact receptors needed to trigger a growth hormone release, reduce inflammation in a joint, or improve insulin sensitivity

Huang J, Gu M, Lai Z, Fan B, Shi K, Zhou YH, Yu JQ, Chen Z

The Clinical Evidence Gap Between Supplements and Prescription GLP-1s Prescription semaglutide demonstrated average weight loss of 9-15% in randomized controlled trials, with some patients losing more than 20% of body weight over one year