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Importantly, both GLP-1RAs and SGLT2i have demonstrated significant reductions in major adverse cardiovascular events (MACEs), heart failure hospitalizations, and renal endpoints in large cardiovascular outcomes trials 135

Nuclear import of insulin-like growth factor-binding protein-3 and -5 is mediated by the importin beta subunit

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Ero1 can be oxidized rapidly in the presence of flavin adenine dinucleotide (FAD) and oxygen, indicating that oxygen is the ultimate electron acceptor (Tu & Weissman, 2002)