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Unspecified diabetic neuropathy (E11.40) should be queried for further specificity, as more specific codes may affect MS-DRG and clinical quality metrics

Shaking the vial can introduce bacteria or other contaminants into the water, so it should be handled gently

NHS approach to B12 deficiency: NICE Clinical Knowledge Summaries recommend investigating B12 deficiency in patients presenting with macrocytic anaemia, unexplained neurological symptoms, or risk factors including pernicious anaemia, gastrectomy, malabsorption disorders, metformin use, proton pump inhibitors, or nitrous oxide exposure

For example, in ASD, there is a strong association between mutations in CDH8 (a gene encoding Cadherin 8, diseases associated with which include craniofacial-deafness-hand syndrome and ectodermal dysplasia) (Jiang et al., 2022)