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Through this intracellular coupling, astrocytes supply neurons with cysteine or cysteinyl-glycine derived from exported GSH, thereby supporting neuronal GSH synthesis and resistance to damaging, redox-driven processes ( When GSH levels are chronically low, immune cells within the CNS shift to a damage-oriented phenotype

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3.2.2 Ferroptosis and parkinsons disease PD is the second most prevalent NDD, characterized by the degeneration and loss of dopaminergic neurons in the substantia nigra of the midbrain

Research indicates that glutathione deficiency is linked to various nervous system diseases like Alzheimer's, Parkinson's, and stroke