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Because a multi-use vial permits drug to be administered to more than 1 patient, waste is reduced significantly and payors reimburse only for what was used, rendering JW or JZ modifiers inapplicable

When handling, use aseptic techniques to prevent contamination

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At each sampling point, cellular Fe 2+ was oxidised to Fe 3+ by addition of potassium dichromate (40 mM final concentration) to prevent further peroxide bond activation, followed by protein precipitation with acetonitrile (containing 150 ng/mL of diazepam as the internal standard) as previously described 28