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The 0.9% benzyl alcohol preservative maintains antimicrobial activity throughout this period, but degradation accelerates with each needle entry, temperature fluctuation above 8C, or exposure to direct light
The continuous turnover of synovial fluid leads to a short residence time for the administered peptides in the joint space, whereas the dense, negatively charged cartilage matrix impedes their diffusive transport
Additionally, it contributes to the body's immune response, helping to strengthen natural defences against infections
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