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Dysbiosis has been associated with an increased permeability of the gut barrier, a condition that allows endotoxins like LPS to enter the bloodstream, triggering an inflammatory response that can contribute to the progression of CKD (Evenepoel et al., 2023)

The concentrations of the various macrospecies comprise the sum of the concentration of those microspecies that contain the same number of protons, for example in GSH: Determination of the redox potential of the GSSG/GSH system was achieved indirectly, applying a redox couple with a known standard redox potential

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Gastrointestinal side-effects can last a few weeks but usually resolve on their own unless a higher dose is taken.